Long-term assessment of bilirubin and transaminase trends in pediatric intestinal failure patients during the era of hepatoprotective parenteral nutrition
Author / Expert
Gregory Keefe, Katherine Culbreath, Jamie Knell, Priyanka V. Chugh, Steven J. Staffa, Tom Jaksic, Biren P. Modi
Topic overview
Abstract
Type of Study
: Retrospective Cohort
Level of Evidence
: III
Purpose
: This study aimed to characterize the relationship between hepatoprotective parenteral nutrition (PN) dependence and long-term serum liver tests in children with intestinal failure (IF).
Methods
: A retrospective review was performed of children with severe IF (>90 consecutive days of PN) who were followed from 2012-2019 at a multidisciplinary intestinal rehabilitation program. Patients were stratified into three groups based on level of PN dependence at most recent follow up: EN (achieved enteral autonomy), mixed (parenteral and enteral nutrition), and PN (>75% of caloric intake from PN). PN at any point for this cohort was hepatoprotective, defined as soy-based lipids
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