Endoplasmic reticulum stress in the acute intestinal epithelial injury of necrotizing enterocolitis

This review examines how endoplasmic reticulum stress and the unfolded protein response contribute to intestinal epithelial cell death in necrotizing enterocolitis, a devastating condition affecting preterm neonates. The authors explore molecular mechanisms linking ER dysfunction to NEC pathogenesis and discuss potential therapeutic strategies to prevent ER stress-induced apoptosis.