The Assessment of Microbiome Changes and Fecal Volatile Organic Compounds during Experimental Necrotizing Enterocolitis

Mouse model study demonstrates that experimental necrotizing enterocolitis produces distinct fecal volatile organic compound profiles detectable by electronic nose technology, correlating with intestinal dysbiosis characterized by reduced Lactobacillus and increased Escherichia species. Findings suggest fecal VOC analysis may offer a non-invasive diagnostic approach for NEC in preterm infants.