Intestinal tract and parenteral multi-organ sequential pathological injury caused by necrotizing enterocolitis

Experimental rat model demonstrates that necrotizing enterocolitis triggers sequential inflammatory injury across multiple organ systems including intestine, lung, liver, and kidney, with varying timelines of damage and repair. Peak injury occurs within 24 hours, with organ repair processes predominating by day 4 and complete resolution by day 7, accompanied by distinct patterns of apoptosis and cellular proliferation markers across affected tissues.