Sedation practices during high dose rate brachytherapy for children with urogenital and perianal rhabdomyosarcoma

Study evaluates a sedation protocol for children undergoing prolonged deep sedation during brachytherapy for urogenital rhabdomyosarcoma. Switching from fentanyl to ketamine three days before extubation significantly reduced ventilator weaning time and PICU length of stay compared to controls, despite withdrawal and delirium occurring in some patients.