Systematic Review and Meta-analysis: Partial External Biliary Diversion in Progressive Familial Intrahepatic Cholestasis

Meta-analysis of 155 PFIC patients demonstrates that post-PEBD serum bile acid levels effectively predict both short-term pruritus relief and long-term transplant-free survival. Bile acid reduction discriminates treatment responders with high accuracy, suggesting its utility as a biomarker for monitoring therapeutic response to enterohepatic circulation interruption.