Autoantibodies and Donor-specific Antibodies are Associated With Graft Dysfunction in Pediatric Liver Transplantation

Retrospective study of 62 pediatric liver transplant recipients found that autoantibodies (43%) and donor-specific HLA antibodies (28%) correlate with biochemical markers of graft dysfunction and increased biopsy frequency. DSA positivity was specifically associated with T-cell-mediated rejection and elevated liver enzymes.