A novel two-component, expandable bioadhesive for exposed defect coverage: applicability to prenatal procedures

Researchers developed and tested a two-component expandable bioadhesive hydrogel for covering spina bifida defects in a fetal rabbit model. The adhesive remained stable in 70% of cases, expanded with fetal growth, and withstood pressures exceeding neonatal cerebrospinal fluid levels, suggesting potential as an alternative approach for prenatal repair of spina bifida and other congenital anomalies.