Bioavailability of rectal acetaminophen in children following anorectal surgery

Study comparing rectal acetaminophen absorption in children after major anorectal surgery (Hirschsprung pull-through, imperforate anus repair) versus inguinal herniotomy. Findings show significantly elevated plasma concentrations in post-anorectal surgery patients, reaching potentially toxic levels, suggesting altered pharmacokinetics require dosing caution in this population.