De novo somatic mutations and KRAS amplification are associated with cholangiocarcinoma in a patient with a history of choledochal cyst

Retrospective study of 48 pediatric choledochal cyst patients found one case of cholangiocarcinoma developing within two years post-resection. Molecular analysis revealed de novo somatic mutations in TP53 and RBM10, plus KRAS amplification in the malignant tissue, underscoring the need for lifelong surveillance despite surgical resection.