Congenital short bowel syndrome: systematic review of a rare condition

Systematic review of 61 congenital short bowel syndrome patients reveals genetic mutations in FLNA and CLMP genes, with malrotation present in 98% of cases. Survival has improved dramatically from 29% pre-2008 to 75% post-2008, though sepsis remains the leading cause of death. The condition appears to follow autosomal recessive or X-linked inheritance patterns.