Gastroschisis prevalence substantially decreased from 2009 through 2018 after a 3-fold increase from 1997 to 2008

Large retrospective study of 1.4 million NICU admissions reveals gastroschisis prevalence tripled from 1997-2008 (2.9 to 6.4 per 1000), then declined 48% by 2018 (3.3 per 1000). Youngest mothers showed highest rates and steepest recent decline, suggesting changing environmental or behavioral risk factors warrant investigation.