Lung function and pulmonary artery blood flow following prenatal maternal retinoic acid and imatinib in the nitrofen model of congenital diaphragmatic hernia

Prenatal retinoic acid administration improved lung maturation, oxygenation, and pulmonary vascular resistance in a rat model of congenital diaphragmatic hernia, while imatinib showed minimal functional benefit. Study demonstrates potential for pharmacologic prenatal interventions to address pulmonary maldevelopment in CDH.