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Neurodevelopmental impairment in necrotising enterocolitis survivors: systematic review and meta-analysis.

Space: StayCurrentMD Author: Archives of Disease in Childhood. Fetal and Neonatal Edition (Matei A, Montalva L, Goodbaum A, Lauriti G, Zani A - curated by Tyare Fuentes SCHCP) Published:

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Archives of Disease in Childhood. Fetal and Neonatal Edition (Matei A, Montalva L, Goodbaum A, Lauriti G, Zani A - curated by Tyare Fuentes SCHCP)
Neurodevelopmental impairment in necrotising enterocolitis survivors: systematic review and meta-analysis. podcast cover art

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AIM: To determine (1) the incidence of neurodevelopmental impairment (NDI) in necrotising enterocolitis (NEC), (2) the impact of NEC severity on NDI in these babies and (3) the cerebral lesions found in babies with NEC.

METHODS: Systematic review: three independent investigators searched for studies reporting infants with NDI and a history of NEC (PubMed, Medline, Cochrane Collaboration, Scopus). Meta-analysis: using RevMan V.5.3, we compared NDI incidence and type of cerebral lesions between NEC infants versus preterm infants and infants with medical vs surgical NEC.

RESULTS: Of 10 674 abstracts screened, 203 full-text articles were examined. In 31 studies (n=2403 infants with NEC), NDI incidence was 40% (IQR 28%-64%) and was higher in infants with surgically treated NEC (43%) compared with medically managed NEC (27%, p

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