Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction

This study identifies decreased anoctamin-1 (ANO1) expression and increased tyrosine phosphorylation in congenital UPJ obstruction tissue compared to controls. The findings suggest that disrupted calcium-activated chloride channel function in smooth muscle cells may impair peristaltic wave transmission, contributing to the pathophysiology of the most common cause of pediatric hydronephrosis.