Neonatal cardiopulmonary transition in an ovine model of congenital diaphragmatic hernia.

This ovine model study characterizes cardiopulmonary transition in CDH, demonstrating that affected newborns have small non-compliant lungs, respiratory acidosis, and reduced cerebral oxygenation. Pulmonary blood flow indexed to lung weight was similar between CDH and control lambs, suggesting reduced PBF is proportional to lung hypoplasia rather than primary vascular dysfunction.