Calcium/calmodulin-dependent protein kinase IV signaling pathway is upregulated in experimental necrotizing enterocolitis

This experimental study demonstrates that calcium/calmodulin-dependent protein kinase IV (CaMKIV) signaling is significantly upregulated in a mouse model of necrotizing enterocolitis. Elevated CaMKIV activation and its downstream inflammatory targets suggest this pathway may contribute to NEC pathogenesis, potentially offering a therapeutic target.