Accelerated Intestinal Epithelial Cell Turnover Correlates with Stimulated BMP Signaling Cascade following Intestinal Ischemia–Reperfusion in a Rat

Rat model study demonstrates that intestinal ischemia-reperfusion injury triggers significant upregulation of BMP2 and BMP4 signaling pathways within 48 hours, correlating with accelerated epithelial cell proliferation and apoptosis. Findings suggest BMP proteins play a key regulatory role in intestinal recovery following ischemic injury.