Extreme Thrombocytosis after Pediatric Pancreatectomy with Islet Autotransplantation Is Unique Compared to Other Postsplenectomy States

Retrospective study of 112 pediatric splenectomy patients reveals that those undergoing pancreatectomy with islet autotransplantation develop extreme thrombocytosis (platelets ≥1000 K/μL) at significantly higher rates (90%) compared to other splenectomy indications (15.7%). IAT patients demonstrate faster platelet rise and higher peak counts, suggesting unique hematologic response requiring distinct monitoring protocols.