Decreased expression of TRAAK channels in Hirschsprung’s disease: a possible cause of postoperative dysmotility

Study demonstrates significant downregulation of TRAAK potassium channels in both aganglionic and ganglionic colon segments of Hirschsprung patients, suggesting these ion channels play a critical role in colonic neurotransmission. Reduced TRAAK expression in ganglionic regions may explain persistent postoperative dysmotility despite surgical correction.