VTE prophylaxis, fertility preservation, and nephron-sparing surgery in pediatric patients

Pediatric trauma patients are at high risk for developing venous thromboembolism.

The Wita et al. cohort study was conducted from 2019 to 2022 in eight pediatric trauma centers and included patients younger than 18 years old.

Among 460 high-risk pediatric trauma patients, more than half received chemical VTE prophylaxis.

Delaying chemical VTE prophylaxis beyond 24 hours of hospital arrival increases the risk of blood clots in high-risk pediatric trauma patients.

VTE prophylaxis is safe and effective for pediatric trauma patients and should be started within 24 hours of admission.

Gillielli et al. performed a systematic retrospective review, initially reviewing 104 abstracts and 34 full-text articles, ultimately including 12 studies.

Ovarian tissue cryopreservation was performed in 501 patients, with 5.9% undergoing ovarian tissue transplantation.

After ovarian tissue transplantation, 33% of patients were able to become pregnant.

Ovarian tissue cryopreservation has advantages for pediatric cancer patients but needs further study.

The Lee et al. systematic review and meta-analysis from Chongqing, China evaluated efficacy and long-term renal function after nephron-sparing surgery in patients with unilateral Wilms tumor.

The meta-analysis included 26 studies.

Nephron-sparing surgery increased glomerular filtration rate after surgery compared to radical nephrectomy.

Nephron-sparing surgery showed no significant differences in overall survival, recurrences, hypertension, or renal dysfunction compared to radical nephrectomy for unilateral Wilms tumor.