Microbial alteration of small bowel stoma effluents and colonic feces in infants with short bowel syndrome

This prospective study of 7 SBS infants reveals distinct microbial communities between small bowel stoma effluents and colonic feces, with stoma samples showing higher bacterial diversity and abundance of Proteobacteria. Compared to healthy controls, SBS patients demonstrate significant dysbiosis with overabundant Proteobacteria, depleted SCFA-producing bacteria, and impaired metabolic pathways, suggesting microbiome alterations persist throughout the intestinal tract in SBS.