Urinary nerve growth factor: a biomarker for detrusor overactivity in children? A meta-analysis and trail sequential analysis

Meta-analysis of three studies (144 children) found urinary nerve growth factor normalized to creatinine (NGF/Cr) was significantly elevated in pediatric detrusor overactivity patients versus controls and decreased after treatment. Trail sequential analysis indicates more studies needed to confirm NGF/Cr as a reliable noninvasive biomarker for childhood overactive bladder.