How Many Lymph Nodes Are Enough? Assessing the Adequacy of Lymph Node Yield for Staging in Favorable Histology Wilms Tumor

Mathematical modeling using National Cancer Database data suggests sampling 6-10 lymph nodes during surgery for favorable histology Wilms tumor reduces the risk of missing occult metastatic disease to ≤10%. This finding provides objective guidance for surgical lymph node sampling to ensure accurate staging and appropriate adjuvant therapy selection.