Neurodevelopmental impairment in children with congenital diaphragmatic hernia: Not an uncommon complication for survivors
Author / Expert
Louise Montalva, Gabriele Raffler, Angela Riccio, Giuseppe Lauriti, Augusto Zani
Topic overview
Abstract
Purpose
To evaluate neurodevelopmental impairment (NDI) in children born with congenital diaphragmatic hernia (CDH).
Methods
Using a defined search strategy, a systematic review was conducted to define the incidence and types of NDI, to report abnormal neuroimaging findings and to evaluate possible NDI predictors. A meta-analysis was performed on comparative studies reporting risk factors for NDI, using RevMan 5.3.
Results
Of 3541 CDH children (33 studies), 829 (23%) had NDI, with a higher incidence in CDH survivors who received ECMO treatment (49%) vs. those who had no ECMO (22%; p
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