Association between image-defined risk factors and neuroblastoma outcomes
Author / Expert
Hannah M. Phelps, Josephine M. Ndolo, Kyle J. Van Arendonk, Heidi Chen, Hannah L. Dietrich, Katherine D. Watson, Melissa A. Hilmes, Dai H. Chung, Harold N. Lovvorn
Topic overview
Abstract
Background
The current neuroblastoma (NBL) staging system employs image-defined risk factors (IDRFs) to assess numerous anatomic features, but the impact of IDRFs on surgical and oncologic outcomes is unclear.
Methods
The Vanderbilt Cancer Registry identified children treated for NBL from 2002 to 2017. Tumor volume (TV) and IDRFs were measured radiographically at diagnosis and before resection. Perioperative and oncologic outcomes were evaluated.
Results
At diagnosis of 106 NBL, 61% were IDRF positive. MYCN-amplified and undifferentiated NBL had more IDRFs than nonamplified and more differentiated tumors (p = 0.001 and p = 0.01). Of 86 NBLs resected, 43% were IDRF positive, which associated with higher stage, risk, and TV (each p
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