Effect of timing of pulmonary metastasis occurrence on the outcome of metastasectomy in osteosarcoma patients

Retrospective study of 88 osteosarcoma patients who underwent pulmonary metastasectomy shows timing of metastasis significantly impacts survival. Patients with metastases appearing after chemotherapy completion had best outcomes (52% 5-year survival), while those developing metastases during treatment had poorest prognosis (8% 5-year survival).