Multicenter pre-operative assessment of pediatric ovarian malignancy
Author / Expert
Topic overview
Abstract
Purpose
The purpose of this study was to develop a pre-operative risk assessment tool for childhood and adolescent ovarian malignancy, in order to guide operative management of pediatric ovarian masses.
Methods
We conducted a retrospective analysis of patients 10 cm) marker-negative heterogeneous lesions had malignancy proportions of 0% (0/39, 95% CI = 0–11%) and 5% (2/40, 95% CI = 1–18%), respectively.
Conclusions
Given the malignancy estimates identified from these multi-institutional data, we recommend an attempt at ovarian-sparing resection for simple cysts or tumor marker-negative heterogeneous lesions ≤10 cm. Oophorectomy is recommended for solid masses or heterogeneous lesions with elevated markers. Finally, large (>10 cm) heterogeneous masses with non-elevated markers warrant a careful discussion of ovarian-sparing techniques. Complete surgical staging is mandatory regardless of operative procedure.
Type of Study
Study of Diagnostic Test.
Level of Evidence
Level I.
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