Clinical features of children with Haddad syndrome: A single-center experience

Retrospective study of 10 pediatric patients with Haddad syndrome demonstrates the dual challenge of managing congenital central hypoventilation and Hirschsprung disease. All patients carried PHOX2B mutations, with 90% requiring tracheostomy and variable colonic aganglionosis patterns. Long-term outcomes show developmental delays in 60% but 100% survival with multidisciplinary care.