MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease

Study demonstrates that elevated mPGES-1-derived PGE2 in Hirschsprung disease inhibits neural crest cell migration through downregulation of EP2 receptor and ARP2/3 complex, causing cytoskeletal damage. Inhibition of mPGES-1 with MK886 reversed these effects, suggesting a novel molecular mechanism underlying HSCR pathogenesis.