Impact of Azygos Vein Preservation on Postoperative Outcomes in Esophageal Atresia: A Systematic Review and Meta-Analysis from the Pediatric Surgery Meta-Analysis (PESMA) Study Group
Topic overview
This meta-analysis from the PESMA Study Group examines whether preserving the azygos vein during EA-TEF repair reduces postoperative complications in neonates. Analysis of seven studies suggests preservation may lower risks of anastomotic leak, chest infection, and mortality, though evidence quality is limited by small sample sizes and heterogeneity.
Key takeaways
- - Azygos vein preservation during EA-TEF repair may reduce anastomotic leaks, chest infections, and mortality compared to ligation. - Meta-analysis of 7 studies (5 RCTs, 2 retrospective) shows trend toward fewer strictures with azygos preservation. - Evidence quality is limited by small sample sizes and heterogeneity; larger RCTs needed to confirm clinical benefit. - Current data suggest azygos preservation is a safe technique worth considering in esophageal atresia repair. - Surgical approach to azygos vein may influence key postoperative complications in neonatal EA-TEF surgery.
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How to cite: GlobalCastMD. Impact of Azygos Vein Preservation on Postoperative Outcomes in Esophageal Atresia: A Systematic Review and Meta-Analysis from the Pediatric Surgery Meta-Analysis (PESMA) Study Group. GlobalCastMD Medical Library. 2026-01-28. https://library.globalcastmd.com/article/11427
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