Is trisomy 21 a risk factor for postoperative complications after pediatric surgery for neonatal gastrointestinal disease? A retrospective study using a National Clinical Database in Japan

This retrospective cohort study uses Japanese national registry data to evaluate whether trisomy 21 increases postoperative complication risk in neonates undergoing gastrointestinal surgery. The research addresses a critical clinical question for surgical planning and family counseling in Down syndrome patients with congenital GI anomalies.