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Topical Mitomycin C Application Versus Intralesional Corticosteroid Injection in the Management of Caustic Esophageal Strictures in Pediatrics: A Randomized Controlled Trial

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Topic overview

This randomized controlled trial compares topical mitomycin C versus intralesional corticosteroid injection as adjuvant therapies for managing caustic esophageal strictures in pediatric patients. Both treatments aim to reduce the need for repeated endoscopic dilatations or esophageal replacement surgery in children with chemical injury-related strictures.

Key takeaways

  • Caustic esophageal strictures in children typically require multiple endoscopic dilatations or esophageal replacement surgery.
  • Topical mitomycin C and intralesional corticosteroids are emerging adjuvant therapies to reduce stricture recurrence.
  • Comparative pediatric data on MMC versus corticosteroid efficacy remains limited, highlighting need for controlled trials.

Keywords

Caustic Esophageal Stricture Mitomycin C Intralesional Corticosteroid Endoscopic Dilatation Pediatric Gastroenterology Esophageal Injury Stricture Management

Hashtags

#PediatricGastroenterology #EsophagealStricture #EndoscopicTherapy #CausticInjury

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How to cite: GlobalCastMD. Topical Mitomycin C Application Versus Intralesional Corticosteroid Injection in the Management of Caustic Esophageal Strictures in Pediatrics: A Randomized Controlled Trial. GlobalCastMD Medical Library. 2025-12-26. https://library.globalcastmd.com/article/11345

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