Prenatal risk stratification and novel treatments for abdominal wall defects: Insights From the APSA fetal diagnosis and treatment committee on evolving practice
Topic overview
This article examines prenatal management strategies for gastroschisis and omphalocele, two congenital abdominal wall defects occurring in approximately 1 in 4000 births. It addresses current controversies including optimal delivery timing, risk stratification methods to distinguish simple from complex gastroschisis, and emerging fetal interventions aimed at reducing bowel inflammation and improving neonatal outcomes.
Key takeaways
- Gastroschisis and omphalocele each occur in ~1 in 4000 live births; omphalocele carries higher risk of in utero demise.
- Prenatal risk stratification aims to distinguish simple from complex gastroschisis to guide delivery timing and intervention.
- Bowel exposure to amniotic fluid in gastroschisis causes inflammation and dysfunction, driving need for fetal interventions.
- Advances in NICU care, parenteral nutrition, and surgical techniques have reduced perinatal mortality for abdominal wall defects.
- Key controversies include optimal delivery timing and assessment of fetal interventions to improve gastroschisis outcomes.
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How to cite: GlobalCastMD. Prenatal risk stratification and novel treatments for abdominal wall defects: Insights From the APSA fetal diagnosis and treatment committee on evolving practice. GlobalCastMD Medical Library. 2025-10-17. https://library.globalcastmd.com/article/11130
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