Letter to the editor: Odds ratio versus risk ratios: Rejuvenating an important debate and an opportunity to learn

Topic overview

Key takeaways

• Odds ratios and risk ratios are distinct effect measures; choosing the appropriate metric depends on study design and outcome prevalence.
• In neonatal critical care research, effect measure selection impacts clinical interpretation and generalizability of surgical intervention studies.
• Methodological transparency in systematic reviews requires explicit justification of statistical approaches, especially in meta-analyses.
• Letters to the editor serve as valuable peer discourse for refining research methodology and advancing evidence-based practice standards.
• Understanding effect measure properties prevents misinterpretation of treatment effects in high-risk populations like critically ill neonates.

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