Internal anal sphincter achalasia in chronic functional constipation in children: A myth rather than reality
Topic overview
This study investigates whether internal anal sphincter achalasia (IASA) in children with chronic functional constipation represents a true pathological entity or simply a functional variant. The research examines children presenting with absent rectoanal inhibitory reflex on manometry but normal ganglion cells on biopsy, questioning the clinical validity of IASA as a distinct diagnosis.
Key takeaways
- IASA is defined by absent RAIR on manometry with normal ganglion cells on biopsy, distinguishing it from Hirschsprung disease.
- Study challenges whether IASA is a true pathologic entity or simply a functional variant within the spectrum of chronic constipation.
- Absent RAIR in constipated children with normal rectal biopsy may not warrant a separate diagnostic category from functional constipation.
- Manometric findings alone may be insufficient to diagnose IASA without considering broader clinical and pathophysiologic context.
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How to cite: GlobalCastMD. Internal anal sphincter achalasia in chronic functional constipation in children: A myth rather than reality. GlobalCastMD Medical Library. 2025-09-24. https://library.globalcastmd.com/article/11036
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