Silent messengers in the nano-world: Harnessing extracellular vesicles as theranostic tools for neonatal surgical conditions
Topic overview
This article explores how extracellular vesicles—nanoparticles that enable cell-to-cell communication—may serve as both diagnostic markers and therapeutic tools for congenital diaphragmatic hernia. The focus is on understanding how disrupted EV signaling during fetal lung development contributes to pulmonary hypoplasia and hypertension in CDH patients.
Key takeaways
- Extracellular vesicles (EVs) are nanoparticles that transfer proteins, lipids, and nucleic acids between cells for intercellular communication.
- MicroRNAs within EVs regulate organogenesis, particularly coordinating multiple cell types during fetal lung development.
- In CDH, disrupted EV-mediated signaling causes pulmonary hypoplasia and hypertension—the main drivers of poor outcomes.
- EVs represent potential theranostic tools for diagnosing and treating neonatal surgical conditions like CDH.
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How to cite: GlobalCastMD. Silent messengers in the nano-world: Harnessing extracellular vesicles as theranostic tools for neonatal surgical conditions. GlobalCastMD Medical Library. 2025-09-16. https://library.globalcastmd.com/article/10999
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