Microenvironmental TFPI2 in Hirschsprung Disease: Mechanisms in ENCC Development
Author / Expert
Dong Sun, Xintao Zhang, Xue Ren, Yu Zhou, Qiongqian Xu, Jichang Han, Chuncan Ma, Weizhen Wang, Xiaoyang Liu, Jiamin Li, Jian Wang, Qiangye Zhang, Dongming Wang, Weijing Mu, Peimin Hou, Aiwu Li
Topic overview
Hirschsprung disease (HSCR) is a relatively common disorder in pediatric surgery, characterized by the absence of enteric ganglion cells due to defective colonization of enteric neural crest cells (ENCCs) in the intestine. This study aims to investigate alterations in the intestinal microenvironment, focusing on the tissue factor pathway inhibitor 2 (TFPI2) as a potential pathogenic factor.
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