Hirschsprung’s disease (HD) is a congenital condition characterised by aganglionosis in the distal bowel. Over the years, at the National Children’s Research Centre (NCRC), HD has been one of the most prominent and successful research areas for Prof. Prem Puri’s research team. Research fellows from around the world came to the NCRC to work on both animal and human studies of HD and, cumulatively, made important discoveries in this field, publishing a total of 144 HD articles in peer-reviewed journals. Through their published work, the NCRC has been recognised as the leading international centre for the investigation of HD and its allied disorders. In this review, I will summarise the main findings from this work.
