Invited Commentary on Sadeghi, et al: Sentinel Lymph Node Biopsy in Pediatric Wilms Tumor

In the treatment of cancer, identifying lymph node (LN) metastasizes are critically important.[1], [2] However, it can be a challenge to identify the “right” node or excise the correct number of nodes to be certain that cancer is or is not present. In adult cancers, the use of a minimum number of nodes and biopsy of a sentinel lymph node have now become standard practice.[3] This is less so for pediatric cancers. Identifying LN positive disease in Wilms tumors is essential as LN positivity has been shown to be the most important predictive factors in long term outcome[1], [4–6].