Long-term assessment of bilirubin and transaminase trends in pediatric intestinal failure patients during the era of hepatoprotective parenteral nutrition

Type of Study

: Retrospective Cohort

Level of Evidence

: III

Purpose

: This study aimed to characterize the relationship between hepatoprotective parenteral nutrition (PN) dependence and long-term serum liver tests in children with intestinal failure (IF).

Methods

: A retrospective review was performed of children with severe IF (>90 consecutive days of PN) who were followed from 2012-2019 at a multidisciplinary intestinal rehabilitation program. Patients were stratified into three groups based on level of PN dependence at most recent follow up: EN (achieved enteral autonomy), mixed (parenteral and enteral nutrition), and PN (>75% of caloric intake from PN). PN at any point for this cohort was hepatoprotective, defined as soy-based lipids