Conversion the Intestinal Smooth Muscle Cells of Hirschsprung’s Disease into Enteric Neurons-like Cells by Small Molecule Compounds

The enteric nervous system (ENS), often referred to as the "second brain," is a complex network of neurons and glial cells in the gut wall, crucial for regulating its functions. Defects in the ENS can lead to Hirschsprung’s disease (HSCR), a serious congenital disorder affecting approximately 1 in 5,000 live births. A promising approach is ENS transplantation. However, obtaining sufficient non-gene edited ENS remains a significant challenge.