Lichen Sclerosus: A black hole in current knowledge and management

We read with interest the study by Neville et al. [1], “Clinical and Histological Predictors of Disease Severity in Boys with Lichen Sclerosus”. The authors describe an intraoperative clinical grading system for lichen sclerosus (LS) and assess its correlation with histopathology and one-year outcomes. The finding that neither clinical appearance nor histological severity predicted the need for reintervention highlights the difficulty of anticipating LS progression based only on morphology.