A Comparative Study of Neural and Connective Tissue Markers in Pediatric and Adult Cases with Ureteropelvic Junction Obstruction

The pathogenesis of ureteropelvic junction obstruction (UPJO) remains unclear, with both neuronal and connective tissue components implicated in its development. Understanding the histopathological mechanisms of UPJO is essential for optimizing treatment strategies and predicting disease progression. This study aimed to investigate age-related differences in neuronal function, synaptic activity, and connective tissue remodeling in pediatric and adult UPJO patients using immunohistochemical markers.