Development of a novel tubular scaffold for tissue-engineered small intestine

Infants with short bowel syndrome (SBS) have significant morbidity and mortality, especially if they depend on parenteral nutrition. Tissue-engineered small intestine (TESI) has been considered a potential therapeutic option for SBS but normal peristaltic function remains a challenge. The purpose of this study was to develop a novel tubular scaffold that promotes smooth muscle cell (SMC) alignment and ultimately peristalsis of TESI constructs.