Long-term outcome after partial splenectomy compared to total splenectomy in children with spherocytosis

Splenectomy may be required for Hereditary Spherocytosis (HS) management. The severe infection risk after total splenectomy (TS) has led to an increasing interest in partial splenectomy (PS). Previous studies suspected that PS may be less effective, but long-term studies are lacking. Here, we compared the long-term efficacy of TS and PS.This French national multicenter retrospective study (2005-2017) included 96 children with a minimum post-surgery follow-up of 5 years. The primary endpoint was the hemoglobin concentration at the follow-up end.