Reevaluating Surgical Antibiotic Prophylaxis in Pediatric Pyloromyotomy: Insights From the NSQIP-Pediatric Database

Pyloromyotomy is a clean surgical procedure with a low risk of surgical site infections (SSIs). Despite this, surgical antibiotic prophylaxis (SAP) is often administered, raising concerns about unnecessary antibiotic exposure and antimicrobial resistance. This study aims to evaluate whether SAP reduces SSI rates in infants undergoing pyloromyotomy for hypertrophic pyloric stenosis and to propose a guideline for selective SAP omission.