Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for....
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More about chromosome abnormalities
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What the experts said
Many centers require genetic testing to rule out chromosome abnormalities before fetal surgery, even when ultrasounds and blood tests already look reassuring
A study reviewed nearly 1000 pregnancies evaluated for fetal surgery
When imaging and cell-free DNA screening showed low risk for aneuploidy, the FISH test matched those results 100% of the time
For low-risk pregnancies, FISH did not provide any new information that changed surgery candidacy
In carefully selected low-risk cases, non-invasive screening may be enough, potentially avoiding the FISH procedure