Early enteral feeding versus traditional feeding in neonatal congenital gastrointestinal malformation undergoing intestinal anastomosis

Infographic · Dec 2021 · 1 min read

In brief

Multicenter RCT of 156 neonates found early enteral feeding after intestinal anastomosis for congenital GI malformations was safe with no significant difference in time to full feeds or length of stay compared to traditional feeding. Results support early feeding as a viable approach without increased complications.

Early enteral feeding after intestinal anastomosis in neonates with GI malformations is safe with no increased complication rates
Time to full feeds averaged 15 days with early feeding vs 18 days with traditional feeding, though difference not statistically significant
No significant differences in feeding intolerance, parenteral nutrition duration, or 30-day mortality between early and traditional feeding
Multicenter RCT of 156 neonates supports feasibility of early feeding protocols post-anastomosis in congenital GI malformations
Post-operative outcomes showed trend toward improvement with early enteral feeding, warranting larger studies

Written by the GCMD Library team from the infographic.

The infographic uses a red and teal color scheme with icons representing a hospital, TPN bag, and warning triangle. On the left, an illustration shows a newborn with intestinal anastomosis highlighted. The center displays comparative outcomes in a grid layout with icons and bar charts showing length of stay, TPN days, and complications between two feeding protocols.

Purpose

the aim of this clinical trial was to evaluate the safety and efficacy of early enteral feeding (EEN) following intestinal anastomosis in neonates with congenital gastrointestinal malformation.

Methods

a multicenter, prospective, randomized controlled trial (registered under chictr.org.cn Identifier no.ChiCTR-INR-17014179) was conducted between 2018 and 2019. Four centers in China analyzed 156 newborns of congenital gastrointestinal malformation undergoing intestinal anastomosis to EEN group (n = 78) or control (C) group (n = 78). The primary outcomes of this study were length of postoperative stay (LOPS) and time to full feeds. Secondary outcomes included morbidity of complications, parenteral nutrition (PN) duration, feeding intolerance, 30 day mortality rate and 30 day readmission rate.

Results

the mean time to full feeds and LOPS in the EEN group were 15.0 (9.8–22.8) days and 17.6 (12.0–29.8) days, while that were 18.0 (12.0–24.0) days and 20.0 (15.0–30.3) days in C groups respectively. There was no significant difference between two groups(P >0.05). No significant intergroup difference was found with respect to postoperative morbidity, PN duration or feeding intolerance(P >0.05).

Conclusions

early enteral feeding following intestinal anastomosis in neonates with congenital gastrointestinal malformation is safe. Post-operative outcomes demonstrated a trend toward improvement.

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