Female Fertility Cryopreservation Outcomes in Childhood Cancer: A Systematic Review
Topic overview
Systematic review examining ovarian tissue cryopreservation outcomes in 612 female childhood cancer patients across 7 countries. Among patients who underwent tissue transplantation and desired pregnancy, 33% achieved pregnancy with 67% resulting in live births, though long-term pediatric data remains limited.
Key takeaways
- Ovarian tissue cryopreservation (OTC) is increasingly used in pediatric cancer patients to preserve fertility before gonadotoxic treatment.
- Among 501 pediatric patients who underwent OTC, only 5.9% later had ovarian tissue transplantation, with 33% achieving pregnancy.
- Most cryopreservation data comes from high-income countries and adult patients; long-term pediatric outcomes remain understudied.
- Hematologic malignancies (81%), CNS tumors (56%), and sarcomas (39%) were the most common cancers in patients undergoing OTC.
- Standardized fertility preservation guidelines for pediatric cancer patients are needed, especially for prepubertal populations.
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